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为微生物药物发现、成药性评价及产业化开发

1. Huang T, Lv Z, Cui K, Wang X, Zhang X, Yue B, Chu Y*, Zhao K*. Involvement of the E3 ubiquitin ligase Cblb in host defense and evaluation of transcriptome during Trueperella pyogenes infection. Microbes Infect. 2023 Jan 19:105104. doi: 10.1016/j.micinf.2023.105104.
2. Liu C, Guo Y, Li L, Li J, Wang L, Lin J, Wang X, Chu Y*. Acrocarpospora catenulata sp. nov., a novel actinobacterium isolated from lake sediment. Int J Syst Evol Microbiol. 2022 Sep;72(9). doi: 10.1099/ijsem.0.005526.
3. Huang T, Zeng M, Fu H, Zhao K, Song T, Guo Y, Zhou J, Zhai L, Liu C, Prithiviraj B, Wang X, Chu Y*. A novel antibiotic combination of linezolid and polymyxin B octapeptide PBOP against clinical Pseudomonas aeruginosa strains. Ann Clin Microbiol Antimicrob. 2022 Aug 29;21(1):38. doi: 10.1186/s12941-022-00531-5.
4. Zhao K, Li J, Yang X, Zeng Q, Liu W, Wu Y, Zhou H, Prithiviraj B, Wang X, Zhou X*, Chu Y*. Subinhibitory Cefotaxime and Levofloxacin Concentrations Contribute to Selection of Pseudomonas aeruginosa in Coculture with Staphylococcus aureus. Appl Environ Microbiol. 2022 Jun 28;88(12):e0059222. doi: 10.1128/aem.00592-22.
5. Huang T, Zhao K, Song X, Song T, Wang X, Zhang X, Yue B, Chu Y*. Heterologous Prime-Boost Immunization with DNA Vaccine and Modified Recombinant Proteins Enhances Immune Response against Trueperella pyogenes in Mice. Vaccines (Basel). 2022 May 25;10(6):839. doi: 10.3390/vaccines10060839.
6. Huang T, Lv Z, Lin J, Zhao K, Zhai L, Wang X, Chu Y*. A Potent Antibiotic Combination of Linezolid and Polymycin B Nonapeptide Against Klebsiella pneumoniae Infection In Vitro and In Vivo. Front Pharmacol. 2022 Apr 26;13:887941. doi: 10.3389/fphar.2022.887941.
7. Liu C, Guo Y, Li L, Wang X, Lin J, Wang X, Li J, Chu Y*. Catellatospora sichuanensis sp. nov., a novel actinobacterium isolated from soil. Int J Syst Evol Microbiol. 2020 May;70(5):3309-3315. doi: 10.1099/ijsem.0.004175.
8. Wang Z, Li X, Tian J, Chu Y*, Tian Y*. Cloning, heterologous expression and characterization of a novel streptomyces trypsin in Bacillus subtilis SCK6. Int J Biol Macromol. 2020 Mar 15;147:890-897. doi: 10.1016/j.ijbiomac.2019.09.248.
9. Huang T, Cui K, Song X, Jing J, Lin J, Wang X, Zhang X, Chu Y*, Yue B*. MTOR involved in bacterial elimination against Trueperella pyogenes infection based on mice model by transcriptome and biochemical analysis. Vet Microbiol. 2019 Aug;235:199-208. doi: 10.1016/j.vetmic.2019.06.021.
10. Zhao K, Yuan Y, Li J, Pan W, Yan C, Fu H, Lin J, Yue B, Wang X, Gou X, Chu Y*, Zhou Y*. Phenotypic and genetic characterization of Pseudomonas aeruginosa isolate COP2 from the lungs of COPD patients in China. Pathog Dis. 2019 Jun 1;77(4):ftz038. doi: 10.1093/femspd/ftz038.
11. Zhao K, Li J, Huang T, Yuan Y, Lin J, Yue B, Wang X, Chu Y*. Coexistence of Microbial Species in Structured Communities by Forming a Hawk-Dove Game Like Interactive Relationship. Front Microbiol. 2019 Apr 16;10:807. doi: 10.3389/fmicb.2019.00807.
12. Zhao K, Ma J, Wang X, Guo Y, Yue B*, Chu Y*. Population divergence of Pseudomonas aeruginosa can lead to the coexistence with Escherichia coli in animal suppurative lesions. Vet Microbiol. 2019 Apr;231:169-176. doi: 10.1016/j.vetmic.2019.03.014.
13. Zhao K, Liu L, Chen X, Huang T, Du L, Lin J, Yuan Y, Zhou Y, Yue B, Wei K, Chu Y*. Behavioral heterogeneity in quorum sensing can stabilize social cooperation in microbial populations. BMC Biol. 2019 Mar 6;17(1):20. doi: 10.1186/s12915-019-0639-3.
14. Wang Z, Tian J, Li X, Gan L, He L, Chu Y*, Tian Y*. Streptomyces dioscori sp. nov., a Novel Endophytic Actinobacterium Isolated from Bulbil of Dioscorea bulbifera L. Curr Microbiol. 2018 Oct;75(10):1384-1390. doi: 10.1007/s00284-018-1534-9.
15. Zhao K, Du L, Lin J, Yuan Y, Wang X, Yue B, Wang X, Guo Y, Chu Y*, Zhou Y*. Pseudomonas aeruginosa Quorum-Sensing and Type VI Secretion System Can Direct Interspecific Coexistence During Evolution. Front Microbiol. 2018 Oct 11;9:2287. doi: 10.3389/fmicb.2018.02287.
16. Li X, Wang Z, Lu F, Zhang H, Tian J, He L, Chu Y*, Tian Y*. Actinocorallia populi sp. nov., an endophytic actinomycete isolated from a root of Populus adenopoda (Maxim.). Int J Syst Evol Microbiol. 2018 Jul;68(7):2325-2330. doi: 10.1099/ijsem.0.002840.

一、科研项目：
1. 国家卫计委“十三五”重大新药创制专项，耐药菌防治药物品种及共性关键技术研发：抗耐药细菌药物筛选及体内外评价技术体系，201901-202012，177.72万元，主持；
2. 四川省国际科技合作重点项目，基于宿主机制的抗耐药菌新药筛选关键技术的研发及应用，201801-202012，50万元，主持；
3. 国家科技基础条件平台科技基础资源调查专项，湖泊微生物多样性及资源调查，201702-202201，75万元，主持；
4. 四川省科研平台建设项目，202001-202012，50万元，主持；
5. 成都市科技重大项目，新抗生素创制及产业化协同创新，201701-202012，800万元，主持；
6. 成都市科技局国际科技合作项目，秀丽隐杆线虫耐药菌感染高通量体内模型建立及新药筛选，201801-202012,20万元，主持；
二、获奖情况：
1. 2019年度河北省科技进步一等奖——《发酵类免疫抑制药物的关键技术开发及产业化》（排名第三）
2. 2020年度第十五届中国药学会科学技术一等奖——《器官移植抗排斥微生物药物的关键技术开发及产业化》（排名第三）