拉斯维加斯(9888·VIP认证)游戏官网-Web Game Platform

肿瘤细胞衰老，小分子的化学生物学调控机制及靶点

1. Peng T, He Y, Wang T, Yu J, Ma X, Zhou Z, Sheng Y, Li L, Peng H, Li S, Zou J, Yuan Y, Zhao Y, Shi H, Li F, Liu W, Hu K, Lu X, Zhang G, Wang F. Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis. J Med Chem. 2022 Aug 25;65(16):11010-11033. doi: 10.1021/acs.jmedchem.2c00189. Epub 2022 Jun 13. PMID: 35695407.
2. Zhou Z, Li Y, Ma X, Cao B, Peng T, Sheng Y, Peng H, Li R, Cao Y, Xi R, Li F, Wang M, Sun H, Zhang G, Zhang H, Hu K, Xiao W, Wang F. Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma. J Med Chem. 2021 Jun 10;64(11):7404-7421. doi: 10.1021/acs.jmedchem.1c00018. Epub 2021 May 26. PMID: 34038111.
3. Peng T, Wonganan O, Zhang Z, Yu J, Xi R, Cao Y, Suksamrarn A, Zhang G, Wang F. A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating β-TrCP E3 Ubiquitin Ligase. Int J Mol Sci. 2021 Mar 25;22(7):3354. doi: 10.3390/ijms22073354. PMID: 33805945; PMCID: PMC8036434.
4. Zhang X, Peng T, Shi X, Fang D, Tang L, Chen F, Wang F, Zhang G, Luo Y. Diterpenoids caryopterisoids D - Q and iridoid glucoside derivatives caryopterisides F - H from Caryopteris glutinosa. Phytochemistry. 2020 Dec;180:112534. doi: 10.1016/j.phytochem.2020.112534. Epub 2020 Oct 13. PMID: 33065407.
5. Ebokaiwe AP, Njoya EM, Sheng Y, Zhang Z, Li S, Zhou Z, Qiang Z, Peng T, Hussein AA, Zhang G, Lu X, Li L, Wang F. Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells. Toxicol Appl Pharmacol. 2020 Oct 1;404:115203. doi: 10.1016/j.taap.2020.115203. Epub 2020 Aug 19. PMID: 32822738.
6. Qiang Z, Zhou ZY, Peng T, Jiang PZ, Shi N, Njoya EM, Azimova B, Liu WL, Chen WH, Zhang GL, Wang F. Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D. J Exp Clin Cancer Res. 2018 Nov 27;37(1):288. doi: 10.1186/s13046-018-0971-4. PMID: 30482227; PMCID: PMC6260752.
7. Du BW, Zhang XJ, Shi N, Peng T, Gao JB, Azimova B, Zhang R, Pu DB, Wang C, Abduvaliev A, Rakhmanov A, Zhang GL, Xiao WL, Wang F. Luteolin-7-methylether from Leonurus japonicus inhibits estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19). Eur J Pharmacol. 2020 Jul 15;879:173154. doi: 10.1016/j.ejphar.2020.173154. Epub 2020 Apr 29. PMID: 32360836.
8. Peng T, Zhuo L, Wang Y, Jun M, Li G, Wang L, Hong D. Systematic review of sodium thiosulfate in treating calciphylaxis in chronic kidney disease patients. Nephrology (Carlton). 2018 Jul;23(7):669-675. doi: 10.1111/nep.13081. PMID: 28603903.
9. Peng T, Li G, Zhong X, Wang L. Does copy number variation of APOL1 gene affect the susceptibility to focal segmental glomerulosclerosis? Ren Fail. 2017 Nov;39(1):500-504. doi: 10.1080/0886022X.2017.1323646. PMID: 28494221; PMCID: PMC6014314.
10. Peng T, Wang L, Li G. The analysis of APOL1 genetic variation and haplotype diversity provided by 1000 Genomes project. BMC Nephrol. 2017 Aug 11;18(1):267. doi: 10.1186/s12882-017-0675-6. PMID: 28800731; PMCID: PMC5553676.
11. 钟翔，彭婷，涂月菊，李贵森，王莉.WISP-1在IgA肾病患者中的表达与肾间质纤维化的关系[J].中华肾脏病杂志,2017,33(9):649-655.
12. 彭婷，李贵森.载脂蛋白L1基因突变及其相关疾病的研究进展[J].中华肾脏病杂志,2016,32(5):395-400.

纵向课题：
1. 国家自然科学基金青年科学基金项目，2024.01-2026.12，主持
2. 四川省自然科学基金青年科学基金项目，2023.01-2024.12，主持
3. 抗生素研究与再评价四川省重点实验室开放课题，2023.05-2024.05，主持
4. 成都大学引进人才启动项目, 2022.10-2027.10，主持
授权专利：
1. 王飞，卢晓霞，张国林，王涛，彭婷，一种miRNA生物合成抑制剂专利，CN 109810071 A.
教学成果:
1. 成都大学《创新育人—拉斯维加斯游戏官网9888生物化学实验教学体系的建设与改革》实验教改项目
2. 成都大学《人类健康与疾病》综合素养课程